Throughout history, as humans spread and occupied our planet, many infectious diseases emerged. From the time of Ancient Greece to the present, epidemics have resulted in about one billion deaths worldwide. Some of the most devastating infectious diseases are: TYPHUS, INFLUENZA, SMALLPOX, PLAGUE, MEASLES, YELLOW FEVER, HEPATITIS, DENGUE FEVER, CHOLERA, ENCEPHALITIS, POLIOMYELITIS, MALARIA, AIDS, MENINGITIS, EBOLA, SARS, PERTUSSIS, PNEUMONIA AND TUBERCULOSIS, Currently, the COVID-19, one of the viruses in the Coronavirus family, is sweeping throughout the world spreading fear, panic and death, it is important to look back at the five most lethal epidemics in history, based on the total number of deaths relative to the population at the time.
1. PLAGUE OF ATHENS (429-426 B.C.)
When the epidemic erupted, the Peloponesian war was being waged in Greece between Sparta and Athens, the latter under the leadership of the prominent Athenian statesman, orator and brilliant general Pericles. It is generally believed that the disease originated in Ethiopia and entered Athens on merchant ships through the harbour of Piraeus, Athens, which was the only source of food and supplies from overseas. The disease became a highly contagious epidemic, most likely of typhus, typhoid fever or viral hemorrhagic. According to the Greek historian Thucydides, the victims of the disease suddenly developed high fever, headache and inflammation, with red eyes, a bleeding throat and tongue, diarrhea and the vomiting of blood. Some victims also developed gangrene at the tips of the fingers and toes. Most of the sick died in seven days. It is estimated that the plague killed 25% of the Athenian troops and 75,000 to 100,000 Athenians, or one-third of the Athenian population. Among the people who died were Pericles, his wife, and his two sons. Although Thucydides contracted the plague, he managed to survive. The plague also spread to the eastern Mediterranean, but to a less degree. Scholars believe that because the Athenians were losing the war, they were forced to retreat and the overcrowding in the City contributed to the spreading of the disease. The plague created fear, panic and chaos in the city. Athenians became discontent, lost faith in freedom and democracy and started to disobey the law, which was one of the main reasons for the decline and collapse of the golden age of Pericles
PLAGUE OF ATHENS (429-426 B.C.)
2. ANTONINE PLAGUE (165-180 A.D.)
The Antonine Plague (named after the Roman Emperor Marcus Aurelius Antoninus), that severely affected the Roman Empire, erupted in 165 A.D., when Roman power was at its peak throughout the Mediterranean world. The Greek physician Galen describes the disease as being of long duration, with fever, diarrhea, pharyngitis, and pustules of fluid and pus on the skin. It may have been smallpox, brought to Rome from China via merchant ships and by Roman troops returning from campaigns in the near East. The Roman historian Dio Cassius reports that there were up to 2,000 deaths a day in Rome, 25% of those who were infected. The plague also devastated the Roman army. It is estimated that between 60-70 million people, or 25% to 75% of the total population of the Empire, perished. Even the Emperor Antonine was infected and died. The plague had drastic social and political effects throughout the Roman Empire. It brought chaos and political and economic instability. The large number of deaths reduced the workforce, resulting in lower production of goods and services, and reduced trade and hence lower tax revenue for the government. The Romans also experienced civil wars and invasions by barbarians. People left their urban centres believing that they were cursed. Some were looking for answers in mystical religious and magic places, but the majority turned to Christianity which provided them with a meaning for life in times of crisis. Christianity also promised salvation in the afterlife, a solace in times of death and tragedy.
ANTONINE PLAGUE (165-180 A.D.)
3. JUSTINIAN PLAGUE (541-542 A.D.)
The Justinian plague occurred from 541-542 A.D. in the Byzantine Empire, during the rule of the Roman Emperor Justinian the First. The plague also afflicted the Sasanian Empire and port cities around the Mediterranean Sea. The Byzantine Empire, sometimes known as the Eastern Roman Empire because it was the eastern half of the Roman Empire, was mainly Greek-speaking. Its capital city was Constantinople. In 541 A.D., trade was flourishing in the Empire, and merchant ships carrying grain from Egypt to Constantinople harboured rats carrying fleas infected with the disease, thus spreading it throughout the Empire. Even the emperor Justinian contracted the plague, but survived. The Greek Byzantine scholar and historian Procopious writes in his history that the victim suffered from fever, chills, swollen lymph nodes under the armpits and behind the ears, abdominal and groin pain and gangrene. A number of the deceased fell into a coma for days before death and others died immediately on becoming ill. Dead bodies were left stacked in the open since there was no room to bury them and the entire city of Constantinople smelled like dead flesh. The plague decimated Constantinople and reached a point when about 5,000 people died daily. The total loss of life in the City was 40% and the total death toll in the Empire was approximately 25 million people. Gradually the plague spread to Europe, Asia, North Africa and Arabia and resulted in 30 to 50 million deaths, which accounted for about half of Europe’s population at the time. The decimation of the population caused high labour shortages, which had a tremendous impact on the military and economic power of the Byzantine Empire and resulted in its decline.The high mortality rate of the plague had a profoundly negative impact on the world at the time.
JUSTINIAN PLAGUE (541-542 A.D.)
4. BLACK DEATH (1347-1351 A.D.)
In the middle of the 14th century, and specifically in 1348, a very devastating global pandemic known as the Black Plague spread throughout Asia, North Africa and Europe. The disease arrived in Italy on rat infected ships coming from Asia to the Black Sea via Sicily. Most of the sailors on the ships were already dead upon arrival. Over the next five years the plague spread throughout Europe, resulting in 25 million deaths, one-third of Europe’s population. Medical knowledge had stagnated during the Middle Ages (or medieval period), mainly because the Church was very influential at the time and suppressed science and technological development. The Church also considered cats evil creatures and had ordered that all cats, that could have killed the rats, be eliminated. In parts of Europe the plague killed 2000 people a day, and in many crowded European cities, such as Paris, Florence, Hamburg and London, half or more of the population died. The Church was hard-hit because priests, monks and nuns cared for the diseased and became ill themselves. The total number of deaths in Europe, Asia and North Africa surpassed 200 million. In the Middle East, especially in Iran, Iraq and Syria, over one third of the population died, and 40% of Egypt’s population. The Italian writer Giovanni Boccaccio, who resided in Florence at the time and lived through the plague, writes that Infected fleas that attached themselves to rats and then to humans spread the plague and the victim developed swelling, tumors on the neck, armpits or groin and most died within a week. Others were infected by breathing the exhaled air of the diseased and affected their respiratory system and blood. The Black Death pandemic was characterized by swelling, developing tumors, darkening the body, bleeding under the skin and gangrene of the fingers, toes, and nose. It is believed that the plague finally ended through the use of quarantine. At the end of the pandemic, the huge decline in population in Europe brought severe labour shortages and skyrocketing wages, and it took a long time for the economies to recover. It took Europe nearly 200 years to regain the same population that had existed before the disease.
BLACK DEATH (1347-1351 A.D.)
5.THE SPANISH INFLUENZA (1918-1920 A.D.)
The influenza pandemic of 1918, was the most severe in recent history. Although the exact origin of this pandemic is unknown, it is believed to have been of avian origin. It was given the name Spanish Influenza (Flu) because it was first reported in Spain. Spain had not taken part in the First World War and the Spanish media were therefore not censored, and were free to report the news. The flu first appeared in Europe, America and parts of Asia and gradually spread worldwide. One theory is that the flu originated in China, and came into Europe when the British and French governments recruited Chinese workers as laborers to perform manual work while their own citizens were engaged in the War. The disease spread rapidly and governments ordered the closure of public places, schools, libraries, theatres, churches and other places that led to public gatherings. People were obligated to wear masks, avoid close contact with each other and stay indoors. The disease was an unusually lethal influenza, affecting all ages.The skin of the victim turned blue and the lungs filled with fluid leading to suffocation. Victims died within hours or days after having developed symptoms of the flu, and 25 million people died during the first 25 weeks of the outbreak. It is estimated that 500 million people, or one-third of the world’s population, were infected with the virus, and up to 100 million died worldwide. These are approximate numbers since no medical records were reported in many places. The pandemic lasted for two years. It is considered the deadliest pandemic in human history, and was probably worsened by the lack of nutrition and the appalling conditions of the soldiers and citizens during and after World War One. More American soldiers died of the Spanish flu than were killed in the War. The flu ended by the autumn of 1920. The economic repercussions were devastating. Real Gross Domestic Product (GDP) and consumption per Capita of the average country (adjusted for inflation) were reduced by between 6 to 8%., and in financial markets real stock returns (adjusted for inflation) were -26%.
THE SPANISH INFLUENZA (1918-1920 A.D.)

